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Is there an optimal number of item-ship-to combinations for supply planning?

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We have a large number of item-ship-to combinations (25,000+/month).  I'm thinking of using planning hierarchies as one way of combining ship-to locations into regions and also thinking that we should combine items as well.  I understand that 25,000 is a large number of items for supply planning (SNP using CTM). As I work to simplify, is there a target or optimal number that I should try to reach?  Thank you!


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